Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

Multidrug resistance (MDR) is a major impediment to the success of chemotherapy in many cancer types. One particular MDR mechanism is the inherent or acquired adaptation of the cellular survival pathways that render malignant cells resistant to apoptotic cell death. Since most drugs act through apop...

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Detalles Bibliográficos
Autores principales: Chow, Mun Juinn, Licona, Cynthia, Pastorin, Giorgia, Mellitzer, Georg, Ang, Wee Han, Gaiddon, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013925/
https://www.ncbi.nlm.nih.gov/pubmed/30155055
http://dx.doi.org/10.1039/c6sc00268d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013925/
https://www.ncbi.nlm.nih.gov/pubmed/30155055
http://dx.doi.org/10.1039/c6sc00268d

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