Cargando…

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

Accumulation of aggregated α-synuclein into Lewy bodies is thought to contribute to the onset and progression of dopaminergic neuron degeneration in Parkinson's disease (PD) and related disorders. Although protein aggregation is associated with perturbation of proteostasis, how α-synuclein aggr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ugras, Scott, Daniels, Malcolm J., Fazelinia, Hossein, Gould, Neal S., Yocum, Anastasia K., Luk, Kelvin C., Luna, Esteban, Ding, Hua, McKennan, Chris, Seeholzer, Steven, Martinez, Dan, Evans, Perry, Brown, Daniel, Duda, John E., Ischiropoulos, Harry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014061/ https://www.ncbi.nlm.nih.gov/pubmed/29759483 http://dx.doi.org/10.1016/j.ebiom.2018.05.007

Ejemplares similares

Co-Inhibition of the Immunoproteasome Subunits LMP2 and LMP7 Ameliorates Immune Thrombocytopenia
por: Du, Sheng-hong, et al.
Publicado: (2021)

Immunohistochemical Identification and Assessment of the Location of Immunoproteasome Subunits LMP2 and LMP7 in Acquired Cholesteatoma
por: Rutkowska, Justyna, et al.
Publicado: (2023)

Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders
por: Kimura, Hiroaki, et al.
Publicado: (2015)

Immunoproteasome subunit ß5i/LMP7-deficiency in atherosclerosis
por: Hewing, Bernd, et al.
Publicado: (2017)

The Immunoproteasome Subunits LMP2, LMP7 and MECL-1 Are Crucial Along the Induction of Cerebral Toxoplasmosis
por: French, Timothy, et al.
Publicado: (2021)

The immunoproteasome subunit LMP10 mediates angiotensin II-induced retinopathy in mice
por: Wang, Shuai, et al.
Publicado: (2018)

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7
por: Vachharajani, Niyati, et al.
Publicado: (2017)

Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection
por: Dimasuay, Kris Genelyn, et al.
Publicado: (2022)

Expression of Immunoproteasome Subunit LMP7 in Breast Cancer and Its Association with Immune-Related Markers
por: Lee, Miseon, et al.
Publicado: (2019)

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice
por: Koerner, Julia, et al.
Publicado: (2017)

Impairment of Immunoproteasome Function by β5i/LMP7 Subunit Deficiency Results in Severe Enterovirus Myocarditis
por: Opitz, Elisa, et al.
Publicado: (2011)

Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction
por: Kim, Minji, et al.
Publicado: (2023)

Inhibition of the Immunoproteasome Subunit LMP7 Ameliorates Cerebral White Matter Demyelination Possibly via TGFβ/Smad Signaling
por: Chen, Xingyong, et al.
Publicado: (2021)

A selective inhibitor of the immunoproteasome subunit LMP2 induces apoptosis in PC-3 cells and suppresses tumour growth in nude mice
por: Wehenkel, M, et al.
Publicado: (2012)

Nitric oxide-dependent CYP2B degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2
por: Sun, Haiyan, et al.
Publicado: (2012)

Ageing-related changes in the levels of β-catenin, CacyBP/SIP, galectin-3 and immunoproteasome subunit LMP7 in the heart of men
por: Kasacka, Irena, et al.
Publicado: (2020)

M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models
por: Sanderson, Michael P., et al.
Publicado: (2021)

Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis
por: Schmidt, Christian, et al.
Publicado: (2018)

Comparative Assessment of the WNT/β-Catenin Pathway, CacyBP/SIP, and the Immunoproteasome Subunit LMP7 in Various Histological Types of Renal Cell Carcinoma
por: Piotrowska, Żaneta, et al.
Publicado: (2020)

Deficiency of the Immunoproteasome LMP10 Subunit Attenuates Angiotensin II-Induced Cardiac Hypertrophic Remodeling via Autophagic Degradation of gp130 and IGF1R
por: Yan, Wen, et al.
Publicado: (2020)

Expression Pattern of Immunoproteasome Subunits in Human Thymus
por: Oh, Kwon Ik, et al.
Publicado: (2009)

The Functional and Mechanistic Roles of Immunoproteasome Subunits in Cancer
por: Tripathi, Satyendra Chandra, et al.
Publicado: (2021)

HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation
por: Yang, Yang, et al.
Publicado: (2020)

Immunoproteasome impairment via β5i/LMP7‐deletion leads to sustained pancreatic injury from experimental pancreatitis
por: de Freitas Chama, Laura L., et al.
Publicado: (2021)

Oxyphylla A Promotes Degradation of α-Synuclein for Neuroprotection via Activation of Immunoproteasome
por: Zhou, Hefeng, et al.
Publicado: (2019)

Deficient immunoproteasome assembly drives gain of α-synuclein pathology in Parkinson's disease
por: Bi, Mingxia, et al.
Publicado: (2021)

Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
por: Mor, Danielle E., et al.
Publicado: (2017)

Applied statistical mechanics : thermodynamic and transport properties of fluids
por: Reed, Thomas M. (Thomas McKennan)
Publicado: (1973)

Immunoproteasome LMP2 60HH Variant Alters MBP Epitope Generation and Reduces the Risk to Develop Multiple Sclerosis in Italian Female Population
por: Mishto, Michele, et al.
Publicado: (2010)

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway
por: Chen, Xing-Yong, et al.
Publicado: (2021)

Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease
por: Han, Deqiang, et al.
Publicado: (2020)

Immunoproteasome Assembly: Cooperative Incorporation of Interferon γ (IFN-γ)–inducible Subunits
por: Griffin, Thomas A., et al.
Publicado: (1998)

A Nut for Every Bolt: Subunit-Selective Inhibitors of the Immunoproteasome and Their Therapeutic Potential
por: Huber, Eva M., et al.
Publicado: (2021)

The Convergence of Dopamine and α-Synuclein: Implications for Parkinson’s Disease
por: Mor, Danielle E, et al.
Publicado: (2018)

The Expression of the Immunoproteasome Subunit PSMB9 Is Related to Distinct Molecular Subtypes of Uterine Leiomyosarcoma
por: Maia Falcão, Raul, et al.
Publicado: (2022)

Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling
por: Bangasser, Debra, et al.
Publicado: (2016)

scMD: cell type deconvolution using single-cell DNA methylation references
por: Cai, Manqi, et al.
Publicado: (2023)

Immunoproteasome Activity in Chronic Lymphocytic Leukemia as a Target of the Immunoproteasome-Selective Inhibitors
por: Besse, Andrej, et al.
Publicado: (2022)

SAT652 The Expression Of The Immunoproteasome Subunit Psmb9 Is Related To Obesity And The Differentiation Of Human Preadipocytes
por: Cui, Yan, et al.
Publicado: (2023)

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis
por: Macedo, Diana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_teimsfaqiv3g9j2cmjjvk2997k