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On the prevalence of bridged macrocyclic pyrroloindolines formed in regiodivergent alkylations of tryptophan
A Friedel–Crafts alkylation is described that efficiently transforms tryptophan-containing peptides into macrocycles of varying ring connectivity. Factors are surveyed that influence the distribution of regioisomers, with a focus on indole C3-alkylations leading to bridged endo-pyrroloindolines. We...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014094/ https://www.ncbi.nlm.nih.gov/pubmed/30155060 http://dx.doi.org/10.1039/c5sc04612b |