Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants

Inherited peroxisomal biogenesis disorders (PBDs) are characterized by the absence of functional peroxisomes. They are caused by mutations of peroxisomal biogenesis factors encoded by Pex genes, and result in childhood lethality. Owing to the many metabolic functions fulfilled by peroxisomes, PBD pa...

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Detalles Bibliográficos
Autores principales: Bülow, Margret H., Wingen, Christian, Senyilmaz, Deniz, Gosejacob, Dominic, Sociale, Mariangela, Bauer, Reinhard, Schulze, Heike, Sandhoff, Konrad, Teleman, Aurelio A., Hoch, Michael, Sellin, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014165/
https://www.ncbi.nlm.nih.gov/pubmed/29282281
http://dx.doi.org/10.1091/mbc.E17-08-0535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014165/
https://www.ncbi.nlm.nih.gov/pubmed/29282281
http://dx.doi.org/10.1091/mbc.E17-08-0535

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