Current CRISPR gene drive systems are likely to be highly invasive in wild populations

Recent reports have suggested that self-propagating CRISPR-based gene drive systems are unlikely to efficiently invade wild populations due to drive-resistant alleles that prevent cutting. Here we develop mathematical models based on existing empirical data to explicitly test this assumption for pop...

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Detalles Bibliográficos
Autores principales: Noble, Charleston, Adlam, Ben, Church, George M, Esvelt, Kevin M, Nowak, Martin A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014726/
https://www.ncbi.nlm.nih.gov/pubmed/29916367
http://dx.doi.org/10.7554/eLife.33423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014726/
https://www.ncbi.nlm.nih.gov/pubmed/29916367
http://dx.doi.org/10.7554/eLife.33423

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