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Piperlongumine and p53-Reactivator APR-246 Selectively Induce Cell Death in HNSCC by Targeting GSTP1
TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC) patients without human papillomavirus infection. The recurrence rate for these patients is distinctly high. It has been actively explored to identify agents that target TP53 mutations and restore wild-type (WT) TP53 act...
Autores principales: | Hang, Wei, Yin, Zhi-Xian, Liu, Gang, Zeng, Qinghua, Shen, Xiang-Feng, Sun, Qian-Hui, Li, Dong-Dong, Jian, Yong-Ping, Zhang, Yang-He, Wang, Yi-Shu, Quan, Cheng-Shi, Zhao, Rui-Xun, Li, Yu-Lin, Xu, Zhi-Xiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014869/ https://www.ncbi.nlm.nih.gov/pubmed/29348462 http://dx.doi.org/10.1038/s41388-017-0110-2 |
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