New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K

Plasma untargeted metabolomics is a common method for evaluation of the mechanisms underlying human pathologies and identification of novel biomarkers. The plasma proteins provide the environment for transport of hydrophobic metabolites. The current sample preparation protocol relies on the immediat...

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Detalles Bibliográficos
Autores principales: Wawrzyniak, Renata, Kosnowska, Anna, Macioszek, Szymon, Bartoszewski, Rafał, Jan Markuszewski, Michał
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015025/
https://www.ncbi.nlm.nih.gov/pubmed/29934622
http://dx.doi.org/10.1038/s41598-018-27983-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015025/
https://www.ncbi.nlm.nih.gov/pubmed/29934622
http://dx.doi.org/10.1038/s41598-018-27983-0

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