The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development

Smad ubiquitin regulatory factor 1 (SMURF1) is a HECT-type E3 ubiquitin ligase that plays a critical role in vertebrate development by regulating planar cell polarity (PCP) signaling and convergent extension (CE). Here we show that SMURF1 is involved in mammalian heart development. We find that SMUR...

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Detalles Bibliográficos
Autores principales: Koefoed, K., Skat-Rørdam, J., Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, F., Pedersen, L. B., Wrana, J. L., Anderson, R. H., Møllgård, K., Christensen, S. T., Larsen, L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015040/
https://www.ncbi.nlm.nih.gov/pubmed/29934521
http://dx.doi.org/10.1038/s41598-018-27854-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015040/
https://www.ncbi.nlm.nih.gov/pubmed/29934521
http://dx.doi.org/10.1038/s41598-018-27854-8

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