Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Huntington’s disease is caused by the pathological expansion of a polyglutamine (polyQ) stretch in Huntingtin (Htt), but the molecular mechanisms by which polyQ expansion in Htt causes toxicity in selective neuronal populations remain poorly understood. Interestingly, heterologous expression of expa...

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Detalles Bibliográficos
Autores principales: Zhao, Yanding, Zurawel, Ashley A., Jenkins, Nicole P., Duennwald, Martin L., Cheng, Chao, Kettenbach, Arminja N., Supattapone, Surachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015068/
https://www.ncbi.nlm.nih.gov/pubmed/29934597
http://dx.doi.org/10.1038/s41598-018-27900-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015068/
https://www.ncbi.nlm.nih.gov/pubmed/29934597
http://dx.doi.org/10.1038/s41598-018-27900-5

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