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Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species

Huntington’s disease is caused by the pathological expansion of a polyglutamine (polyQ) stretch in Huntingtin (Htt), but the molecular mechanisms by which polyQ expansion in Htt causes toxicity in selective neuronal populations remain poorly understood. Interestingly, heterologous expression of expa...

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Detalles Bibliográficos
Autores principales:	Zhao, Yanding, Zurawel, Ashley A., Jenkins, Nicole P., Duennwald, Martin L., Cheng, Chao, Kettenbach, Arminja N., Supattapone, Surachai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015068/ https://www.ncbi.nlm.nih.gov/pubmed/29934597 http://dx.doi.org/10.1038/s41598-018-27900-5

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