LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration

Cancer cells’ ability to migrate through constricting pores in the tissue matrix is limited by nuclear stiffness. MT1-MMP contributes to metastasis by widening matrix pores, facilitating confined migration. Here, we show that modulation of matrix pore size or of lamin A expression known to modulate...

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Detalles Bibliográficos
Autores principales: Infante, Elvira, Castagnino, Alessia, Ferrari, Robin, Monteiro, Pedro, Agüera-González, Sonia, Paul-Gilloteaux, Perrine, Domingues, Mélanie J., Maiuri, Paolo, Raab, Matthew, Shanahan, Catherine M., Baffet, Alexandre, Piel, Matthieu, Gomes, Edgar R., Chavrier, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015082/
https://www.ncbi.nlm.nih.gov/pubmed/29934494
http://dx.doi.org/10.1038/s41467-018-04865-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015082/
https://www.ncbi.nlm.nih.gov/pubmed/29934494
http://dx.doi.org/10.1038/s41467-018-04865-7

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