Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

Alzheimer’s disease (AD) is characterized by accumulation of tau neurofibrillary tangles (NFTs) and, according to the prion model, transcellular propagation of pathological “seeds” may underlie its progression. Staging of NFT pathology with phospho-tau antibody is useful to classify AD and primary a...

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Detalles Bibliográficos
Autores principales: Kaufman, Sarah K., Del Tredici, Kelly, Thomas, Talitha L., Braak, Heiko, Diamond, Marc I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015098/
https://www.ncbi.nlm.nih.gov/pubmed/29752551
http://dx.doi.org/10.1007/s00401-018-1855-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015098/
https://www.ncbi.nlm.nih.gov/pubmed/29752551
http://dx.doi.org/10.1007/s00401-018-1855-6

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