Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis

PKCβ-null (Prkcb(−/−)) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsui, Carlson, Martinez-Martin, Nuria, Gaya, Mauro, Maldonado, Paula, Llorian, Miriam, Legrave, Nathalie M., Rossi, Merja, MacRae, James I., Cameron, Angus J., Parker, Peter J., Leitges, Michael, Bruckbauer, Andreas, Batista, Facundo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015119/
https://www.ncbi.nlm.nih.gov/pubmed/29884460
http://dx.doi.org/10.1016/j.immuni.2018.04.031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015119/
https://www.ncbi.nlm.nih.gov/pubmed/29884460
http://dx.doi.org/10.1016/j.immuni.2018.04.031

Ejemplares similares