Metabolomic Profiling in Acute ST‐Segment–Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia–Reperfusion Injury

BACKGROUND: Ischemia–reperfusion injury following ST‐segment–elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia–reperfusion injur...

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Detalles Bibliográficos
Autores principales: Kohlhauer, Matthias, Dawkins, Sam, Costa, Ana S. H., Lee, Regent, Young, Timothy, Pell, Victoria R., Choudhury, Robin P., Banning, Adrian P., Kharbanda, Rajesh K., Saeb‐Parsy, Kourosh, Murphy, Michael P., Frezza, Christian, Krieg, Thomas, Channon, Keith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015393/
https://www.ncbi.nlm.nih.gov/pubmed/29626151
http://dx.doi.org/10.1161/JAHA.117.007546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015393/
https://www.ncbi.nlm.nih.gov/pubmed/29626151
http://dx.doi.org/10.1161/JAHA.117.007546

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