Modeling the Transition From Decompensated to Pathological Hypertrophy

BACKGROUND: Long‐chain acyl‐CoA synthetases (ACSL) catalyze the conversion of long‐chain fatty acids to fatty acyl‐CoAs. Cardiac‐specific ACSL1 temporal knockout at 2 months results in a shift from FA oxidation toward glycolysis that promotes mTORC1‐mediated ventricular hypertrophy. We used unbiased...

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Detalles Bibliográficos
Autores principales: Pascual, Florencia, Schisler, Jonathan C., Grevengoed, Trisha J., Willis, Monte S., Coleman, Rosalind A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015423/
https://www.ncbi.nlm.nih.gov/pubmed/29622588
http://dx.doi.org/10.1161/JAHA.117.008293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015423/
https://www.ncbi.nlm.nih.gov/pubmed/29622588
http://dx.doi.org/10.1161/JAHA.117.008293

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