Episomal HBV persistence within transcribed host nuclear chromatin compartments involves HBx

BACKGROUND: In hepatocyte nuclei, hepatitis B virus (HBV) genomes occur episomally as covalently closed circular DNA (cccDNA). The HBV X protein (HBx) is required to initiate and maintain HBV replication. The functional nuclear localization of cccDNA and HBx remains unexplored. RESULTS: To identify...

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Detalles Bibliográficos
Autores principales: Hensel, Kai O., Cantner, Franziska, Bangert, Felix, Wirth, Stefan, Postberg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015472/
https://www.ncbi.nlm.nih.gov/pubmed/29933745
http://dx.doi.org/10.1186/s13072-018-0204-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015472/
https://www.ncbi.nlm.nih.gov/pubmed/29933745
http://dx.doi.org/10.1186/s13072-018-0204-2

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