Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin

Occurrence of oxidative stress is the principal cause of acute kidney injury induced by cisplatin. Mangiferin, a naturally occurring antioxidant molecule, is found to ameliorate several oxidative stress mediated pathophysiological conditions including cancer. Cisplatin induced cytotoxicity was measu...

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Detalles Bibliográficos
Autores principales: Sadhukhan, Pritam, Saha, Sukanya, Dutta, Sayanta, Sil, Parames C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015878/
https://www.ncbi.nlm.nih.gov/pubmed/29967581
http://dx.doi.org/10.3389/fphar.2018.00638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015878/
https://www.ncbi.nlm.nih.gov/pubmed/29967581
http://dx.doi.org/10.3389/fphar.2018.00638

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