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Mangiferin Ameliorates Cisplatin Induced Acute Kidney Injury by Upregulating Nrf-2 via the Activation of PI3K and Exhibits Synergistic Anticancer Activity With Cisplatin

Occurrence of oxidative stress is the principal cause of acute kidney injury induced by cisplatin. Mangiferin, a naturally occurring antioxidant molecule, is found to ameliorate several oxidative stress mediated pathophysiological conditions including cancer. Cisplatin induced cytotoxicity was measu...

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Detalles Bibliográficos
Autores principales:	Sadhukhan, Pritam, Saha, Sukanya, Dutta, Sayanta, Sil, Parames C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015878/ https://www.ncbi.nlm.nih.gov/pubmed/29967581 http://dx.doi.org/10.3389/fphar.2018.00638

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