Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requis...

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Detalles Bibliográficos
Autores principales: Wei, Ting, Najmi, Saman M., Liu, Hester, Peltonen, Karita, Kucerova, Alena, Schneider, David A., Laiho, Marikki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016085/
https://www.ncbi.nlm.nih.gov/pubmed/29642000
http://dx.doi.org/10.1016/j.celrep.2018.03.066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016085/
https://www.ncbi.nlm.nih.gov/pubmed/29642000
http://dx.doi.org/10.1016/j.celrep.2018.03.066

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