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Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is enforced is not known. Here, we define key elements requis...

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Detalles Bibliográficos
Autores principales:	Wei, Ting, Najmi, Saman M., Liu, Hester, Peltonen, Karita, Kucerova, Alena, Schneider, David A., Laiho, Marikki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016085/ https://www.ncbi.nlm.nih.gov/pubmed/29642000 http://dx.doi.org/10.1016/j.celrep.2018.03.066

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