Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies

2-Deoxy-d-ribose-5-phosphate aldolase (DERA) is used in organic synthesis for the enantioselective reaction between acetaldehyde and a broad range of other aldehydes as acceptor molecules. Nevertheless, its application is hampered by a poor tolerance towards high concentrations of acetaldehyde, its...

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Detalles Bibliográficos
Autores principales: Dick, Markus, Hartmann, Rudolf, Weiergräber, Oliver H., Bisterfeld, Carolin, Classen, Thomas, Schwarten, Melanie, Neudecker, Philipp, Willbold, Dieter, Pietruszka, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016325/
https://www.ncbi.nlm.nih.gov/pubmed/30155096
http://dx.doi.org/10.1039/c5sc04574f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016325/
https://www.ncbi.nlm.nih.gov/pubmed/30155096
http://dx.doi.org/10.1039/c5sc04574f

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