Divergent enantioselective synthesis of hapalindole-type alkaloids using catalytic asymmetric hydrogenation of a ketone to construct the chiral core structure

A divergent enantioselective approach to hapalindole-type alkaloids is described. The route features a ruthenium-catalyzed asymmetric hydrogenation of a ketone via DKR to construct the chiral trans-1-indolyl-2-isopropenylcyclohexane skeleton and a switchable sequence of methylation and acetylation/a...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Cheng, Li-Jie, Yue, Hai-Tao, Che, Wen, Xie, Jian-Hua, Zhou, Qi-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016446/
https://www.ncbi.nlm.nih.gov/pubmed/30155122
http://dx.doi.org/10.1039/c6sc00686h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016446/
https://www.ncbi.nlm.nih.gov/pubmed/30155122
http://dx.doi.org/10.1039/c6sc00686h

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