Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1

The high-energy sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby red...

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Detalles Bibliográficos
Autores principales: Mueller, Jonathan W., Idkowiak, Jan, Gesteira, Tarsis F., Vallet, Cecilia, Hardman, Rebecca, van den Boom, Johannes, Dhir, Vivek, Knauer, Shirley K., Rosta, Edina, Arlt, Wiebke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/
https://www.ncbi.nlm.nih.gov/pubmed/29743239
http://dx.doi.org/10.1074/jbc.RA118.002248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/
https://www.ncbi.nlm.nih.gov/pubmed/29743239
http://dx.doi.org/10.1074/jbc.RA118.002248

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