Cargando…

Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1

The high-energy sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby red...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mueller, Jonathan W., Idkowiak, Jan, Gesteira, Tarsis F., Vallet, Cecilia, Hardman, Rebecca, van den Boom, Johannes, Dhir, Vivek, Knauer, Shirley K., Rosta, Edina, Arlt, Wiebke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/ https://www.ncbi.nlm.nih.gov/pubmed/29743239 http://dx.doi.org/10.1074/jbc.RA118.002248

Ejemplares similares

A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio
por: Haring, Robin, et al.
Publicado: (2013)

3′-Phosphoadenosine 5′-Phosphosulfate (PAPS) Synthases, Naturally Fragile Enzymes Specifically Stabilized by Nucleotide Binding
por: van den Boom, Johannes, et al.
Publicado: (2012)

SAT-114 Loss of DHEA-Targeting SULT2b1b Sulfotransferase Exacerbates Aggressive Traits of Prostate Cancer
por: Song, Chung Seog, et al.
Publicado: (2020)

In rats, oral oleoyl-DHEA is rapidly hydrolysed and converted to DHEA-sulphate
por: Serrano, Marta, et al.
Publicado: (2007)

Time-dependence of dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEAS), and cortisol in survivors and non-survivors of severe sepsis
por: Marx, C, et al.
Publicado: (2002)

Do Dehydroepiandrosterone (DHEA) and Its Sulfate (DHEAS) Play a Role in the Stress Response in Domestic Animals?
por: Gabai, Gianfranco, et al.
Publicado: (2020)

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations
por: Hocking, Henry G., et al.
Publicado: (2008)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
por: Cunningham, Christian N., et al.
Publicado: (2008)

A Common Theme in Interaction of Bacterial Immunoglobulin-binding Proteins with Immunoglobulins Illustrated in the Equine System
por: Lewis, Melanie J., et al.
Publicado: (2008)

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION
por: Alexandrov, Ilya M., et al.
Publicado: (2008)

Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
por: Grummitt, Charles G., et al.
Publicado: (2008)

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE
por: da Fonseca, Paula C. A., et al.
Publicado: (2008)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Structure-Function Analysis of the C3 Binding Region of Staphylococcus aureus Immune Subversion Protein Sbi
por: Upadhyay, Abhishek, et al.
Publicado: (2008)

Structural Constraints for the Binding of Short Peptides to Claudin-4 Revealed by Surface Plasmon Resonance
por: Ling, Jun, et al.
Publicado: (2008)

Electrostatic and Lipid Anchor Contributions to the Interaction of Transducin with Membranes: MECHANISTIC IMPLICATIONS FOR ACTIVATION AND TRANSLOCATION
por: Kosloff, Mickey, et al.
Publicado: (2008)

Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor: EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE
por: Stoddart, Cheryl A., et al.
Publicado: (2008)

Deciphering the Ligand-binding Sites in the Borrelia burgdorferi Complement Regulator-acquiring Surface Protein 2 Required for Interactions with the Human Immune Regulators Factor H and Factor H-like Protein 1
por: Siegel, Corinna, et al.
Publicado: (2008)

Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration
por: Baraibar, Martin A., et al.
Publicado: (2008)

Synaptotagmin C2B Domain Regulates Ca(2+)-triggered Fusion in Vitro: CRITICAL RESIDUES REVEALED BY SCANNING ALANINE MUTAGENESIS
por: Gaffaney, Jon D., et al.
Publicado: (2008)

Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis
por: Clark, Elizabeth A., et al.
Publicado: (2011)

Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB
por: Benfield, Camilla T. O., et al.
Publicado: (2011)

Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG
por: McDowell, Melanie A., et al.
Publicado: (2011)

Truncation, Randomization, and Selection: GENERATION OF A REDUCED LENGTH c-Jun ANTAGONIST THAT RETAINS HIGH INTERACTION STABILITY
por: Crooks, Richard O., et al.
Publicado: (2011)

Mechanism and Specificity of Pentachloropseudilin-mediated Inhibition of Myosin Motor Activity
por: Chinthalapudi, Krishna, et al.
Publicado: (2011)

Solution Structure of the Mycobacterium tuberculosis EsxG·EsxH Complex: FUNCTIONAL IMPLICATIONS AND COMPARISONS WITH OTHER M. TUBERCULOSIS Esx FAMILY COMPLEXES
por: Ilghari, Dariush, et al.
Publicado: (2011)

Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V
por: Preller, Matthias, et al.
Publicado: (2011)

Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs)
por: Wang, Hui, et al.
Publicado: (2011)

An Undecided Coiled Coil: THE LEUCINE ZIPPER OF Nek2 KINASE EXHIBITS ATYPICAL CONFORMATIONAL EXCHANGE DYNAMICS
por: Croasdale, Rebecca, et al.
Publicado: (2011)

Compensating Stereochemical Changes Allow Murein Tripeptide to Be Accommodated in a Conventional Peptide-binding Protein
por: Maqbool, Abbas, et al.
Publicado: (2011)

Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway
por: Hodson, Charlotte, et al.
Publicado: (2011)

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
por: Hammel, Michal, et al.
Publicado: (2011)

Misfolding of Proteins with a Polyglutamine Expansion Is Facilitated by Proteasomal Chaperones
por: Rousseau, Erwann, et al.
Publicado: (2009)

Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis
por: Guhaniyogi, Jayita, et al.
Publicado: (2009)

Control of Periplasmic Interdomain Thiol:Disulfide Exchange in the Transmembrane Oxidoreductase DsbD
por: Mavridou, Despoina A. I., et al.
Publicado: (2009)

Structure and Orientation of Troponin in the Thin Filament
por: Paul, Danielle M., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_7ntg4repjj95c354b62nu9nf2e