Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins

Intrinsically disordered regions are present in one-third of eukaryotic proteins and are overrepresented in cellular processes such as signaling, suggesting that intrinsically disordered proteins (IDPs) may have a functional advantage over folded proteins. Upon interacting with a partner macromolecu...

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Detalles Bibliográficos
Autores principales: Crabtree, Michael D., Mendonça, Carolina A. T. F., Bubb, Quenton R., Clarke, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016464/
https://www.ncbi.nlm.nih.gov/pubmed/29716994
http://dx.doi.org/10.1074/jbc.RA118.002791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016464/
https://www.ncbi.nlm.nih.gov/pubmed/29716994
http://dx.doi.org/10.1074/jbc.RA118.002791

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