Metformin suppresses UHMWPE particle-induced osteolysis in the mouse calvaria by promoting polarization of macrophages to an anti-inflammatory phenotype

BACKGROUND: Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanisms related to excessive bone resorption associated with osteolysis and the damag...

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Detalles Bibliográficos
Autores principales: Yan, Zhao, Tian, Xiaoxi, Zhu, Jinyu, Lu, Zifan, Yu, Lifeng, Zhang, Dawei, Liu, Yanwu, Yang, Chongfei, Zhu, Qingsheng, Cao, Xiaorui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016863/
https://www.ncbi.nlm.nih.gov/pubmed/30134793
http://dx.doi.org/10.1186/s10020-018-0013-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016863/
https://www.ncbi.nlm.nih.gov/pubmed/30134793
http://dx.doi.org/10.1186/s10020-018-0013-x

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