Design, Synthesis and Docking Studies of Flavokawain B Type Chalcones and Their Cytotoxic Effects on MCF-7 and MDA-MB-231 Cell Lines

Flavokawain B (1) is a natural chalcone extracted from the roots of Piper methysticum, and has been proven to be a potential cytotoxic compound. Using the partial structure of flavokawain B (FKB), about 23 analogs have been synthesized. Among them, compounds 8, 13 and 23 were found in new FKB deriva...

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Detalles Bibliográficos
Autores principales: Abu Bakar, Addila, Akhtar, Muhammad Nadeem, Mohd Ali, Norlaily, Yeap, Swee Keong, Quah, Ching Kheng, Loh, Wan-Sin, Alitheen, Noorjahan Banu, Zareen, Seema, Ul-Haq, Zaheer, Shah, Syed Adnan Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017189/
https://www.ncbi.nlm.nih.gov/pubmed/29518053
http://dx.doi.org/10.3390/molecules23030616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017189/
https://www.ncbi.nlm.nih.gov/pubmed/29518053
http://dx.doi.org/10.3390/molecules23030616

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