Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Fibroblast growth factor receptors (FGFRs), a subfamily of receptor tyrosine kinases, are aberrant in various cancer types, and considered to be promising targets for cancer therapy. We started with a weak-active compound that was identified from our internal hepatocyte growth factor receptor (also...

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Detalles Bibliográficos
Autores principales: Jiang, Alan, Liu, Qiufeng, Wang, Ruifeng, Wei, Peng, Dai, Yang, Wang, Xin, Xu, Yechun, Ma, Yuchi, Ai, Jing, Shen, Jingkang, Ding, Jian, Xiong, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017193/
https://www.ncbi.nlm.nih.gov/pubmed/29562726
http://dx.doi.org/10.3390/molecules23030698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017193/
https://www.ncbi.nlm.nih.gov/pubmed/29562726
http://dx.doi.org/10.3390/molecules23030698

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