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Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Fibroblast growth factor receptors (FGFRs), a subfamily of receptor tyrosine kinases, are aberrant in various cancer types, and considered to be promising targets for cancer therapy. We started with a weak-active compound that was identified from our internal hepatocyte growth factor receptor (also...

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Detalles Bibliográficos
Autores principales:	Jiang, Alan, Liu, Qiufeng, Wang, Ruifeng, Wei, Peng, Dai, Yang, Wang, Xin, Xu, Yechun, Ma, Yuchi, Ai, Jing, Shen, Jingkang, Ding, Jian, Xiong, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017193/ https://www.ncbi.nlm.nih.gov/pubmed/29562726 http://dx.doi.org/10.3390/molecules23030698

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