Predicting the Effect of Single and Multiple Mutations on Protein Structural Stability

Predicting how a point mutation alters a protein’s stability can guide pharmaceutical drug design initiatives which aim to counter the effects of serious diseases. Conducting mutagenesis studies in physical proteins can give insights about the effects of amino acid substitutions, but such wet-lab wo...

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Detalles Bibliográficos
Autores principales: Dehghanpoor, Ramin, Ricks, Evan, Hursh, Katie, Gunderson, Sarah, Farhoodi, Roshanak, Haspel, Nurit, Hutchinson, Brian, Jagodzinski, Filip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017198/
https://www.ncbi.nlm.nih.gov/pubmed/29382060
http://dx.doi.org/10.3390/molecules23020251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017198/
https://www.ncbi.nlm.nih.gov/pubmed/29382060
http://dx.doi.org/10.3390/molecules23020251

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