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Predicting the Effect of Single and Multiple Mutations on Protein Structural Stability
Predicting how a point mutation alters a protein’s stability can guide pharmaceutical drug design initiatives which aim to counter the effects of serious diseases. Conducting mutagenesis studies in physical proteins can give insights about the effects of amino acid substitutions, but such wet-lab wo...
Autores principales: | Dehghanpoor, Ramin, Ricks, Evan, Hursh, Katie, Gunderson, Sarah, Farhoodi, Roshanak, Haspel, Nurit, Hutchinson, Brian, Jagodzinski, Filip |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017198/ https://www.ncbi.nlm.nih.gov/pubmed/29382060 http://dx.doi.org/10.3390/molecules23020251 |
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