Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols

From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and ma...

Descripción completa

Detalles Bibliográficos
Autores principales: Weber, Patrick, Nasseri, Seyed A., Pabst, Bettina M., Torvisco, Ana, Müller, Philipp, Paschke, Eduard, Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G., Wrodnigg, Tanja M., Stütz, Arnold E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017319/
https://www.ncbi.nlm.nih.gov/pubmed/29558439
http://dx.doi.org/10.3390/molecules23030708
_version_ 1783334722162655232
author Weber, Patrick
Nasseri, Seyed A.
Pabst, Bettina M.
Torvisco, Ana
Müller, Philipp
Paschke, Eduard
Tschernutter, Marion
Windischhofer, Werner
Withers, Stephen G.
Wrodnigg, Tanja M.
Stütz, Arnold E.
author_facet Weber, Patrick
Nasseri, Seyed A.
Pabst, Bettina M.
Torvisco, Ana
Müller, Philipp
Paschke, Eduard
Tschernutter, Marion
Windischhofer, Werner
Withers, Stephen G.
Wrodnigg, Tanja M.
Stütz, Arnold E.
author_sort Weber, Patrick
collection PubMed
description From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and may bear potential as regulators of N-acetyl-d-hexosaminidase activities in vivo.
format Online
Article
Text
id pubmed-6017319
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-60173192018-11-13 Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols Weber, Patrick Nasseri, Seyed A. Pabst, Bettina M. Torvisco, Ana Müller, Philipp Paschke, Eduard Tschernutter, Marion Windischhofer, Werner Withers, Stephen G. Wrodnigg, Tanja M. Stütz, Arnold E. Molecules Article From 1,2;3,4-di-O-isopropylidene-d-galactopyranose, a preliminary series of highly functionalized amino(hydroxymethyl)cyclopentanes was easily available. These amine-containing basic carbasugars featuring the d-galacto configuration are potent inhibitors of the GH20 β-d-hexosaminidases probed and may bear potential as regulators of N-acetyl-d-hexosaminidase activities in vivo. MDPI 2018-03-20 /pmc/articles/PMC6017319/ /pubmed/29558439 http://dx.doi.org/10.3390/molecules23030708 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Weber, Patrick
Nasseri, Seyed A.
Pabst, Bettina M.
Torvisco, Ana
Müller, Philipp
Paschke, Eduard
Tschernutter, Marion
Windischhofer, Werner
Withers, Stephen G.
Wrodnigg, Tanja M.
Stütz, Arnold E.
Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
title Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
title_full Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
title_fullStr Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
title_full_unstemmed Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
title_short Potent GH20 N-Acetyl-β-d-hexosaminidase Inhibitors: N-Substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
title_sort potent gh20 n-acetyl-β-d-hexosaminidase inhibitors: n-substituted 3-acetamido-4-amino-5-hydroxymethyl-cyclopentanediols
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017319/
https://www.ncbi.nlm.nih.gov/pubmed/29558439
http://dx.doi.org/10.3390/molecules23030708
work_keys_str_mv AT weberpatrick potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT nasseriseyeda potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT pabstbettinam potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT torviscoana potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT mullerphilipp potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT paschkeeduard potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT tschernuttermarion potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT windischhoferwerner potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT withersstepheng potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT wrodniggtanjam potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols
AT stutzarnolde potentgh20nacetylbdhexosaminidaseinhibitorsnsubstituted3acetamido4amino5hydroxymethylcyclopentanediols

Ejemplares similares