Identification of Novel Protein Kinase Receptor Type 2 Inhibitors Using Pharmacophore and Structure-Based Virtual Screening

The Protein Kinase Receptor type 2 (RIPK2) plays an important role in the pathogenesis of inflammatory diseases; it signals downstream of the NOD1 and NOD2 intracellular sensors and promotes a productive inflammatory response. However, excessive NOD2 signaling has been associated with various diseas...

Descripción completa

Detalles Bibliográficos
Autores principales: Cruz, Josiane V., Neto, Moysés F. A., Silva, Luciane B., da S. Ramos, Ryan, da S. Costa, Josivan, Brasil, Davi S. B., Lobato, Cleison C., da Costa, Glauber V., Bittencourt, José Adolfo H. M., da Silva, Carlos H. T. P., Leite, Franco H. A., Santos, Cleydson B. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017386/
https://www.ncbi.nlm.nih.gov/pubmed/29463017
http://dx.doi.org/10.3390/molecules23020453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017386/
https://www.ncbi.nlm.nih.gov/pubmed/29463017
http://dx.doi.org/10.3390/molecules23020453

Ejemplares similares