Investigation into Improving the Aqueous Solubility of the Thieno[2,3-b]pyridine Anti-Proliferative Agents

It is now established that the thieno[2,3-b]pyridines are a potent class of antiproliferatives. One of the main issues encountered for their clinical application is their low water solubility. In order to improve this, two strategies were pursued. First, a morpholine moiety was tethered to the molec...

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Detalles Bibliográficos
Autores principales: Zafar, Ayesha, Pilkington, Lisa I., Haverkate, Natalie A., van Rensburg, Michelle, Leung, Euphemia, Kumara, Sisira, Denny, William A., Barker, David, Alsuraifi, Ali, Hoskins, Clare, Reynisson, Jóhannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017400/
https://www.ncbi.nlm.nih.gov/pubmed/29324695
http://dx.doi.org/10.3390/molecules23010145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017400/
https://www.ncbi.nlm.nih.gov/pubmed/29324695
http://dx.doi.org/10.3390/molecules23010145

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