Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

We designed and synthesized carbamates of the clinically-approved HDAC (histone deacetylase) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) in order to validate our previously-proposed hypothesis that these carbamates might serve as prodrugs for hydroxamic acid containing HDAC inhibito...

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Detalles Bibliográficos
Autores principales: King, Kristina, Hauser, Alexander-Thomas, Melesina, Jelena, Sippl, Wolfgang, Jung, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017415/
https://www.ncbi.nlm.nih.gov/pubmed/29393896
http://dx.doi.org/10.3390/molecules23020321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017415/
https://www.ncbi.nlm.nih.gov/pubmed/29393896
http://dx.doi.org/10.3390/molecules23020321

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