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Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

We designed and synthesized carbamates of the clinically-approved HDAC (histone deacetylase) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) in order to validate our previously-proposed hypothesis that these carbamates might serve as prodrugs for hydroxamic acid containing HDAC inhibito...

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Detalles Bibliográficos
Autores principales:	King, Kristina, Hauser, Alexander-Thomas, Melesina, Jelena, Sippl, Wolfgang, Jung, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017415/ https://www.ncbi.nlm.nih.gov/pubmed/29393896 http://dx.doi.org/10.3390/molecules23020321

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