Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists

The opioid pharmacological profile of cis-(−)-N-normetazocine derivatives is deeply affected by the nature of their N-substituents. Here, our efforts were focused on the synthesis and pharmacological evaluation of novel derivatives of the lead LP1, a multitarget opioid analgesic compound featuring a...

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Detalles Bibliográficos
Autores principales: Turnaturi, Rita, Parenti, Carmela, Prezzavento, Orazio, Marrazzo, Agostino, Pallaki, Paschalina, Georgoussi, Zafiroula, Amata, Emanuele, Pasquinucci, Lorella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017588/
https://www.ncbi.nlm.nih.gov/pubmed/29547588
http://dx.doi.org/10.3390/molecules23030677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017588/
https://www.ncbi.nlm.nih.gov/pubmed/29547588
http://dx.doi.org/10.3390/molecules23030677

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