Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids †

We have synthesized a small series of five 3-[4-arylmethoxy)phenyl]propanoic acids employing an easy and short synthetic pathway. The compounds were tested in vitro against a set of four protein targets identified as key elements in diabetes: G protein-coupled receptor 40 (GPR40), aldose reductase (...

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Detalles Bibliográficos
Autores principales: Colín-Lozano, Blanca, Estrada-Soto, Samuel, Chávez-Silva, Fabiola, Gutiérrez-Hernández, Abraham, Cerón-Romero, Litzia, Giacoman-Martínez, Abraham, Almanza-Pérez, Julio Cesar, Hernández-Núñez, Emanuel, Wang, Zhilong, Xie, Xin, Cappiello, Mario, Balestri, Francesco, Mura, Umberto, Navarrete-Vazquez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017591/
https://www.ncbi.nlm.nih.gov/pubmed/29415496
http://dx.doi.org/10.3390/molecules23020340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017591/
https://www.ncbi.nlm.nih.gov/pubmed/29415496
http://dx.doi.org/10.3390/molecules23020340

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