Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance

Cystic fibrosis (CF) is mainly caused by the deletion of Phe 508 (ΔF508) in the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome system. New drugs able to rescue ΔF508-CFTR trafficki...

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Detalles Bibliográficos
Autores principales: Rusnati, Marco, Sala, Davide, Orro, Alessandro, Bugatti, Antonella, Trombetti, Gabriele, Cichero, Elena, Urbinati, Chiara, Di Somma, Margherita, Millo, Enrico, Galietta, Luis J. V., Milanesi, Luciano, Fossa, Paola, D’Ursi, Pasqualina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017603/
https://www.ncbi.nlm.nih.gov/pubmed/29316712
http://dx.doi.org/10.3390/molecules23010120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017603/
https://www.ncbi.nlm.nih.gov/pubmed/29316712
http://dx.doi.org/10.3390/molecules23010120

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