Substrate Binding Switches the Conformation at the Lynchpin Site in the Substrate-Binding Domain of Human Hsp70 to Enable Allosteric Interdomain Communication

The stress-induced 70 kDa heat shock protein (Hsp70) functions as a molecular chaperone to maintain protein homeostasis. Hsp70 contains an N-terminal ATPase domain (NBD) and a C-terminal substrate-binding domain (SBD). The SBD is divided into the β subdomain containing the substrate-binding site (βS...

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Detalles Bibliográficos
Autores principales: Umehara, Kohei, Hoshikawa, Miho, Tochio, Naoya, Tate, Shin-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017645/
https://www.ncbi.nlm.nih.gov/pubmed/29495458
http://dx.doi.org/10.3390/molecules23030528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017645/
https://www.ncbi.nlm.nih.gov/pubmed/29495458
http://dx.doi.org/10.3390/molecules23030528

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