Design, Synthesis, and Biological Evaluation of Axitinib Derivatives

Axitinib is an approved kinase inhibitor for the therapy of advanced metastatic renal cell carcinoma (RCC). It prevents angiogenesis, cellular adhesion, and induces apoptosis of cancer cells. Here, nine axitinib derivatives were designed by replacing the C=C moiety with the N=N group, and the substi...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Na, Liang, Jianqing, Peng, Shengming, Sun, Qiang, Dai, Qiuyun, Dong, Mingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017704/
https://www.ncbi.nlm.nih.gov/pubmed/29570686
http://dx.doi.org/10.3390/molecules23040747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017704/
https://www.ncbi.nlm.nih.gov/pubmed/29570686
http://dx.doi.org/10.3390/molecules23040747

Ejemplares similares