Cargando…

Design, Synthesis, and Biological Evaluation of Axitinib Derivatives

Axitinib is an approved kinase inhibitor for the therapy of advanced metastatic renal cell carcinoma (RCC). It prevents angiogenesis, cellular adhesion, and induces apoptosis of cancer cells. Here, nine axitinib derivatives were designed by replacing the C=C moiety with the N=N group, and the substi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Na, Liang, Jianqing, Peng, Shengming, Sun, Qiang, Dai, Qiuyun, Dong, Mingxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017704/ https://www.ncbi.nlm.nih.gov/pubmed/29570686 http://dx.doi.org/10.3390/molecules23040747

Ejemplares similares

Design, synthesis and biological evaluation of novel betulinic acid derivatives
por: Yang, Shengjie, et al.
Publicado: (2012)

Selenium substituted axitinib reduces axitinib side effects and maintains its anti-renal tumor activity
por: Fu, Ying, et al.
Publicado: (2022)

Benzoxazole derivatives: design, synthesis and biological evaluation
por: Kakkar, Saloni, et al.
Publicado: (2018)

Evaluation of β-Catenin Inhibition of Axitinib and Nitazoxanide in Human Monocyte-Derived Dendritic Cells
por: Azeem, Waqas, et al.
Publicado: (2021)

Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy
por: Bellesoeur, Audrey, et al.
Publicado: (2017)

Photoswitchable Azo- and Diazocine-Functionalized Derivatives of the VEGFR-2 Inhibitor Axitinib
por: Heintze, Linda, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Benzohydrazide Derivatives Containing Dihydropyrazoles as Potential EGFR Kinase Inhibitors
por: Wang, Hai-Chao, et al.
Publicado: (2016)

Design, Synthesis and Preliminary Biological Evaluation of Benzylsulfone Coumarin Derivatives as Anti-Cancer Agents
por: Wang, Tao, et al.
Publicado: (2019)

Axitinib in Metastatic Renal Cell Carcinoma
por: Mittal, Kriti, et al.
Publicado: (2012)

Design, synthesis and biological evaluation of tetrahydroquinoxaline sulfonamide derivatives as colchicine binding site inhibitors
por: Dong, Haiyang, et al.
Publicado: (2023)

Novel Fluorinated 7-Hydroxycoumarin Derivatives Containing an Oxime Ether Moiety: Design, Synthesis, Crystal Structure and Biological Evaluation
por: Wang, Qing-Qing, et al.
Publicado: (2021)

Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation
por: Zhang, Shu-Guang, et al.
Publicado: (2022)

Beyond the Checkpoint: Severe Axitinib-induced Liver Injury
por: Yeo, Yee Hui, et al.
Publicado: (2023)

Evaluating the safety and efficacy of axitinib in the treatment of advanced renal cell carcinoma
por: Gunnarsson, Orvar, et al.
Publicado: (2015)

Resistance to Pembrolizumab and Axitinib in Renal Cell Carcinoma: Clinical and Genomic Evaluation
por: Vlachostergios, Panagiotis J.
Publicado: (2020)

In vitro evaluation of Axitinib and Sorafenib treatment in glioblastoma cell viability and morphology
por: Opriţa, Alexandru, et al.
Publicado: (2023)

Design, Synthesis and Biological Evaluation of Novel Thienylpyridyl- and Thioether-Containing Acetamides and Their Derivatives as Pesticidal Agents
por: Li, Huan, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Novel Piperazine Derivatives as CCR5 Antagonists
por: Liu, Tao, et al.
Publicado: (2013)

Design, Synthesis, and Biological Activity of Novel Ferulic Amide Ac5c Derivatives
por: Zhang, Renfeng, et al.
Publicado: (2021)

Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
por: Wu, Xiaowei, et al.
Publicado: (2021)

ATLAS trial of adjuvant axitinib in patients with renal cell carcinoma: subgroup analyses with focus on axitinib dosing and racial groups
por: Quinn, D.I., et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
por: Xie, Yong-Mei, et al.
Publicado: (2011)

Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers
por: Pithavala, Yazdi K., et al.
Publicado: (2010)

Axitinib for the Management of Metastatic Renal Cell Carcinoma
por: Escudier, Bernard, et al.
Publicado: (2012)

Axitinib: Newly Approved for Renal Cell Carcinoma
por: Tyler, Timothy
Publicado: (2012)

Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo
por: Zhang, Bo-Wen, et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents
por: Zi, Cheng-Ting, et al.
Publicado: (2019)

The Effects of Axitinib plus Tislelizumab in the Treatment of Advanced Renal Cell Carcinoma
por: Wang, Zhixin, et al.
Publicado: (2022)

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers
por: Chu, Yeonjeong, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents
por: Ghasemi, Saeed, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Benzo[D]Thiazole with Dimethylpyrazol Derivatives
por: Liu, Dachuan, et al.
Publicado: (2019)

Design, Synthesis, Biological Evaluation and Silico Prediction of Novel Sinomenine Derivatives
por: Li, Shoujie, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
por: Madia, Valentina Noemi, et al.
Publicado: (2021)

Design, synthesis, and biological evaluation of morpholinopyrimidine derivatives as anti-inflammatory agents
por: Fatima, Sadaf, et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of Pyridineamide Derivatives Containing a 1,2,3-Triazole Fragment as Type II c-Met Inhibitors
por: Xiong, Hehua, et al.
Publicado: (2019)

A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation
por: Xu, Bing, et al.
Publicado: (2015)

Design, Synthesis and Preliminary Biological Evaluation of Novel Benzyl Sulfoxide 2-Indolinone Derivatives as Anticancer Agents
por: Tang, Lin, et al.
Publicado: (2017)

Design, synthesis, and preliminary biological evaluation of catalpol propionates as antiaging drugs
por: Dong, Chunhong, et al.
Publicado: (2019)

Losartan Alleviates the Side Effects and Maintains the Anticancer Activity of Axitinib
por: Fu, Ying, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Neocryptolepine Derivatives as Potential Anti-Gastric Cancer Agents
por: Ma, Yunhao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5fr6aj7cvf7vdo4qb6et8r78lq