Modification of Boc-Protected CAN508 via Acylation and Suzuki-Miyaura Coupling

The cyclin-dependent kinase inhibitor, CAN508, was protected with di-tert-butyl dicarbonate to access the amino-benzoylated pyrazoles. The bromo derivatives were further arylated by Suzuki-Miyaura coupling using the XPhos Pd G2 pre-catalyst. The coupling reaction provided generally the para-substitu...

Descripción completa

Detalles Bibliográficos
Autores principales: Pisár, Martin, Schütznerová, Eva, Hančík, Filip, Popa, Igor, Trávníček, Zdeněk, Cankař, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017724/
https://www.ncbi.nlm.nih.gov/pubmed/29329219
http://dx.doi.org/10.3390/molecules23010149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017724/
https://www.ncbi.nlm.nih.gov/pubmed/29329219
http://dx.doi.org/10.3390/molecules23010149

Ejemplares similares