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Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search

SET7, serving as the only histone methyltransferase that monomethylates ‘Lys-4’ of histone H3, has been proved to function as a key regulator in diverse biological processes, such as cell proliferation, transcriptional network regulation in embryonic stem cell, cell cycle control, protein stability,...

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Detalles Bibliográficos
Autores principales: Ding, Hong, Lu, Wen Chao, Hu, Jun Chi, Liu, Yu-Chih, Zhang, Chen Hua, Lian, Fu Lin, Zhang, Nai Xia, Meng, Fan Wang, Luo, Cheng, Chen, Kai Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017732/
https://www.ncbi.nlm.nih.gov/pubmed/29498708
http://dx.doi.org/10.3390/molecules23030567