Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a potential drug target because of its role in the development of Down syndrome and Alzheimer’s disease. The selective DYRK1A inhibitor 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid (KuFal194), a large, flat and lipophi...

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Detalles Bibliográficos
Autores principales: Meine, Rosanna, Becker, Walter, Falke, Hannes, Preu, Lutz, Loaëc, Nadège, Meijer, Laurent, Kunick, Conrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017736/
https://www.ncbi.nlm.nih.gov/pubmed/29364148
http://dx.doi.org/10.3390/molecules23020064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017736/
https://www.ncbi.nlm.nih.gov/pubmed/29364148
http://dx.doi.org/10.3390/molecules23020064

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