Exploring N-acyl-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-enes as 11β-HSD1 Inhibitors

We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1. In continuation of our efforts to discover potent and selective 11β-HSD1 inhibitors, herein we explored several replacements for the cyclohex...

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Detalles Bibliográficos
Autores principales: Leiva, Rosana, McBride, Andrew, Binnie, Margaret, Webster, Scott P., Vázquez, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017749/
https://www.ncbi.nlm.nih.gov/pubmed/29495550
http://dx.doi.org/10.3390/molecules23030536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017749/
https://www.ncbi.nlm.nih.gov/pubmed/29495550
http://dx.doi.org/10.3390/molecules23030536

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