Exploring N-acyl-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-enes as 11β-HSD1 Inhibitors

We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1. In continuation of our efforts to discover potent and selective 11β-HSD1 inhibitors, herein we explored several replacements for the cyclohexane ring. Some derivatives exhibited potent inhibitory activity against human 11β-HSD1, although with low selectivity over the isoenzyme 11β-HSD2, and poor microsomal stability.