Cargando…

Antileishmanial Activity of 2-Methoxy-4H-spiro-[naphthalene-1,2′-oxiran]-4-one (Epoxymethoxy-lawsone): A Promising New Drug Candidate for Leishmaniasis Treatment

Epoxymethoxy-lawsone is a naphthoquinone derivative promising as drug candidate for the treatment of leishmaniases. In the present work the effectiveness of epoxymethoxylawsone, and meglumine antimoniate on Leishmania (Leishmania) amazonensis parasites and on mice paw lesions of infected BALB/c mice...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oliveira, Luiz Filipe Gonçalves, Souza-Silva, Franklin, de Castro Côrtes, Luzia Monteiro, Cysne-Finkelstein, Lea, de Souza Pereira, Mirian Cláudia, de Oliveira Junior, Francisco Odêncio, Pinho, Rosa Teixeira, Corte Real, Suzana, Bourguignon, Saulo Cabral, Ferreira, Vitor Francisco, Alves, Carlos Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017818/ https://www.ncbi.nlm.nih.gov/pubmed/29642584 http://dx.doi.org/10.3390/molecules23040864

Ejemplares similares

The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis
por: Gonçalves-Oliveira, Luiz Filipe, et al.
Publicado: (2019)

Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate
por: Oliveira, Luiz Filipe Gonçalves, et al.
Publicado: (2017)

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction
por: Fu, Qin, et al.
Publicado: (2013)

2-(4-{4-[4-(Oxiran-2-ylmethoxy)phenoxy]phenyl}phenoxymethyl)oxirane
por: Song, Tao, et al.
Publicado: (2012)

Epoxy-α-lapachone (2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites
por: Peixoto, Juliana Figueiredo, et al.
Publicado: (2023)

3′-(3-Hydroxyphenyl)-4-methylspiro[benzo[e][1,4]diazepine-3,2′-oxirane]-2,5(1H,4H)-dione
por: Liu, Jun-Liang, et al.
Publicado: (2011)

(S)-(+)-4-(Oxiran-2-ylmethoxy)-9H-carbazole
por: Lu, Ding-Qiang, et al.
Publicado: (2010)

Crystal structure of methyl 1-methyl-2-oxospiro[indoline-3,2′-oxirane]-3′-carboxylate
por: Savithri, M. P., et al.
Publicado: (2015)

In Silico Insights into the Mechanism of Action of Epoxy-α-Lapachone and Epoxymethyl-Lawsone in Leishmania spp.
por: Peixoto, Juliana Figueiredo, et al.
Publicado: (2021)

Lawson on Sciatica
Publicado: (1877)

Lawson Tait
Publicado: (1899)

Lawson Tait
Publicado: (1899)

3-(4-Nitrophenyl)-N-phenyloxirane-2-carboxamide
por: He, Long
Publicado: (2009)

3-(4-Cyanophenyl)-N-phenyloxirane-2-carboxamide
por: He, Long
Publicado: (2010)

Antileishmanial Activity of 4,8-Dimethoxynaphthalenyl Chalcones on Leishmania amazonensis
por: de Santiago-Silva, Kaio Maciel, et al.
Publicado: (2022)

Bioactive Steroids Bearing Oxirane Ring
por: Dembitsky, Valery M.
Publicado: (2023)

James Burnett Lawson
Publicado: (1930)

Adam Lawson Kelly
Publicado: (1901)

Dr. Edward Lawson
Publicado: (1870)

Serine Proteinases in Leishmania (Viannia) braziliensis Promastigotes Have Distinct Subcellular Distributions and Expression
por: Santos-de-Souza, Raquel, et al.
Publicado: (2019)

Participation of heparin binding proteins from the surface of Leishmania (Viannia) braziliensis promastigotes in the adhesion of parasites to Lutzomyia longipalpis cells (Lulo) in vitro
por: de Castro Côrtes, Luzia Monteiro, et al.
Publicado: (2012)

Pinnatifidenyne-Derived Ethynyl Oxirane Acetogenins from Laurencia viridis
por: Morales-Amador, Adrián, et al.
Publicado: (2017)

Lawson on Sciatica, Lumbago, and Brachialgia
Publicado: (1872)

Mr. Lawson Tait and Vivisection
por: Ruffer, M. Armand
Publicado: (1893)

Lawson Tait on Bacterial Pathology
Publicado: (1894)

Prof. L. M. Lawson
Publicado: (1850)

Mr. Lawson Tait’s Mistake
Publicado: (1886)

4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
por: Rodrigues, Carina Agostinho, et al.
Publicado: (2018)

Cytotoxic and Antileishmanial Effects of the Monoterpene β-Ocimene
por: de Sousa, Julyanne Maria Saraiva, et al.
Publicado: (2023)

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats
por: Khan, Muhammad, et al.
Publicado: (2023)

1′′-Benzyl-1′-methyl-4′-(naphthalen-1-yl)naphthalene-2-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-1,2′′-dione
por: Selvanayagam, S., et al.
Publicado: (2011)

Kinetoplastid Membrane Protein-11 as a Vaccine Candidate and a Virulence Factor in Leishmania
por: de Mendonça, Sergio Coutinho Furtado, et al.
Publicado: (2015)

Lawson Wilkins: portrait of a pioneer
por: Fuqua, John S, et al.
Publicado: (2014)

Lawson Wilkins: recollections by his daughter
por: McMaster, Elizabeth Wilkins
Publicado: (2014)

Mr. Lawson Tait on Lumbar Colotomy
Publicado: (1898)

Lawson Tait, His Life and Work
Publicado: (1923)

Lawson Tait, F. R. C. S.
Publicado: (1887)

Lawson Tait’s Wonderful Success in Ovariatory
Publicado: (1886)

Letter from Mr. Lawson Tait
por: Tait, Lawson
Publicado: (1894)

1′,1′′-Dimethyl-4′-(naphthalen-1-yl)-1,2,3,4-tetrahydronaphthalene-2-spiro-3′-pyrrolidine-2′-spiro-3′′-indoline-1,2′′-dione
por: Selvanayagam, S., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_00ts0eakv0abensoccrpm2cp92