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Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice
Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017955/ https://www.ncbi.nlm.nih.gov/pubmed/29283418 http://dx.doi.org/10.3390/molecules23010067 |
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author | Ramírez-Espinosa, Juan José Saldaña-Ríos, Johann García-Jiménez, Sara Villalobos-Molina, Rafael Ávila-Villarreal, Gabriela Rodríguez-Ocampo, Angélica Nallelhy Bernal-Fernández, Germán Estrada-Soto, Samuel |
author_facet | Ramírez-Espinosa, Juan José Saldaña-Ríos, Johann García-Jiménez, Sara Villalobos-Molina, Rafael Ávila-Villarreal, Gabriela Rodríguez-Ocampo, Angélica Nallelhy Bernal-Fernández, Germán Estrada-Soto, Samuel |
author_sort | Ramírez-Espinosa, Juan José |
collection | PubMed |
description | Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice (p < 0.05). Moreover, triglyceride blood levels were reduced and IL-1β and TNF-α were diminished after 10 days’ treatment compared with control group (p < 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases. |
format | Online Article Text |
id | pubmed-6017955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60179552018-11-13 Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice Ramírez-Espinosa, Juan José Saldaña-Ríos, Johann García-Jiménez, Sara Villalobos-Molina, Rafael Ávila-Villarreal, Gabriela Rodríguez-Ocampo, Angélica Nallelhy Bernal-Fernández, Germán Estrada-Soto, Samuel Molecules Article Extensive knowledge of diabetes and its complications is helpful to find new drugs for proper treatment to stop degenerative changes derived from this disease. In this context, chrysin (5,7-dihydroxyflavone) is a natural product that occurs in a variety of flowers and fruits with anti-inflammatory and antidiabetic effects, among others. Thus, a diabetic model in athymic nude mice was developed and used to establish the ability of chrysin to decrease the secretion of pro-inflammatory cytokines. Also, it was determined the acute (50 mg/kg) and sub-acute (50 mg/kg/day/10 days) antidiabetic and antihyperlipidemic activities after the period of time treatment. Results indicate that chrysin has significant acute antihyperglycemic and antidiabetic effects in nude diabetic mice (p < 0.05). Moreover, triglyceride blood levels were reduced and IL-1β and TNF-α were diminished after 10 days’ treatment compared with control group (p < 0.05). In conclusion, it was found that chrysin could produce similar effects as metformin, a drug used for the treatment of diabetes, since both test samples decreased glucose and triglycerides levels, they impaired the generation of pro-inflammatory cytokines involved in the development of diabetes and its consequences, such as atherosclerosis and other cardiovascular diseases. MDPI 2017-12-28 /pmc/articles/PMC6017955/ /pubmed/29283418 http://dx.doi.org/10.3390/molecules23010067 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ramírez-Espinosa, Juan José Saldaña-Ríos, Johann García-Jiménez, Sara Villalobos-Molina, Rafael Ávila-Villarreal, Gabriela Rodríguez-Ocampo, Angélica Nallelhy Bernal-Fernández, Germán Estrada-Soto, Samuel Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice |
title | Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice |
title_full | Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice |
title_fullStr | Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice |
title_full_unstemmed | Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice |
title_short | Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice |
title_sort | chrysin induces antidiabetic, antidyslipidemic and anti-inflammatory effects in athymic nude diabetic mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017955/ https://www.ncbi.nlm.nih.gov/pubmed/29283418 http://dx.doi.org/10.3390/molecules23010067 |
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