Accumulation of poly(A) RNA in nuclear granules enriched in Sam68 in motor neurons from the SMNΔ7 mouse model of SMA

Spinal muscular atrophy (SMA) is a severe motor neuron (MN) disease caused by the deletion or mutation of the survival motor neuron 1 (SMN1) gene, which results in reduced levels of the SMN protein and the selective degeneration of lower MNs. The best-known function of SMN is the biogenesis of splic...

Descripción completa

Detalles Bibliográficos
Autores principales: Narcís, J. Oriol, Tapia, Olga, Tarabal, Olga, Piedrafita, Lídia, Calderó, Jordi, Berciano, Maria T., Lafarga, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018117/
https://www.ncbi.nlm.nih.gov/pubmed/29941967
http://dx.doi.org/10.1038/s41598-018-27821-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018117/
https://www.ncbi.nlm.nih.gov/pubmed/29941967
http://dx.doi.org/10.1038/s41598-018-27821-3

Ejemplares similares